A novel portable cell sonoporation device based on open-source acoustofluidics

Bin Song,Wei Zhang,Xue Bai,Lin Feng,Deyuan Zhang,Fumihito Arai,Bin Song,Wei Zhang,Xue Bai,Lin Feng,Deyuan Zhang,Fumihito Arai

Sonoporation, which typically employs acoustic cavitation microbubbles, can enhance the permeability of the cell membrane, allowing foreign matter to enter cells across the natural barriers. However, the diameter nonuniformity and random distribution of microbubbles make it difficult to achieve controllable and high-efficiency sonoporation, while complex extern acoustic driving system also limits ...