Micro Robotic Manipulation System for the Force Stimulation of Muscle Fiber-like Cell Structure

Xie Chen,Qing Shi,Shingo Shimoda,Tao Sun,Huaping Wang,Qiang Huang,Toshio Fukuda,Xie Chen,Qing Shi,Shingo Shimoda,Tao Sun,Huaping Wang,Qiang Huang,Toshio Fukuda

Many previous works have facilitated muscle cell (C2C12) alignment to form fiber-like cell structures. However, there still remains a challenge how to induce C2C12 myoblasts in the cell structures to differentiate into matured myocytes to form a functional muscle tissue, while external mechanical stimulation has been proved to have good effects on proliferation and differentiation of myoblasts. In...