On-chip Continuous Pairing, Separation and Electrofusion of Cells Using a Microdroplet

Naotomo Tottori,Sora Sadamichi,Shinya Sakuma,Tomomi Tsubouchi,Yoko Yamanishi,Naotomo Tottori,Sora Sadamichi,Shinya Sakuma,Tomomi Tsubouchi,Yoko Yamanishi

Cell fusion has been widely applied in scientific research for cancer immunotherapy, antibody production, and nuclear reprogramming of somatic cells, and therefore the cell fusion technique that enable us to precisely control the fusion process with high throughput manner has been desired. Here, we present a novel microfluidic method for automatic cell pairing by microdroplets, separation of dropl...