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within: This journal Full site Perspective Perspective Perspective Volume 187, Issue 22p6125-6151October 31, 2024 Volume 187, Issue 22 Volume 187 Issue 22 p6125-6151 p6125-6151 October 31, 2024 Open access Open access Open access Download Full Issue Shanghua Gao1 ∙ Ada Fang1,2,8,11 ∙ Yepeng Huang1,3,11 ∙ … ∙ Valentina Giunchiglia1,4,11 ∙ Ayush Noori1,5,11 ∙ Jonathan Richard Schwarz1 ∙ Yasha Ektefaie1,6 ∙ Jovana Kondic7 ∙ Marinka Zitnik1,8,9,10 marinka@hms.harvard.edu … Show more Show less Shanghua Gao1 ∙ Ada Fang1,2,8,11 ∙ Yepeng Huang1,3,11 ∙ … ∙ Valentina Giunchiglia1,4,11 ∙ Ayush Noori1,5,11 ∙ Jonathan Richard Schwarz1 ∙ Yasha Ektefaie1,6 ∙ Jovana Kondic7 ∙ Marinka Zitnik1,8,9,10 marinka@hms.harvard.edu … Show more Show less Shanghua Gao1 Shanghua Gao Ada Fang1,2,8,11 Ada Fang Yepeng Huang1,3,11 Yepeng Huang ∙ … ∙ Valentina Giunchiglia1,4,11 Valentina Giunchiglia1,4,11 Valentina Giunchiglia ∙ Ayush Noori1,5,11 Ayush Noori1,5,11 Ayush Noori ∙ Jonathan Richard Schwarz1 Jonathan Richard Schwarz1 Jonathan Richard Schwarz Yasha Ektefaie1,6 Yasha Ektefaie Jovana Kondic7 Jovana Kondic Marinka Zitnik1,8,9,10 marinka@hms.harvard.edu Marinka Zitnik … Show more Show more Show more Show less Show less 1 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA 2 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA 3 Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA 4 Department of Brain Sciences, Imperial College London, London, UK 5 Harvard College, Cambridge, MA, USA 6 Program in Biomedical Informatics, Harvard Medical School, Boston, MA, USA 7 Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA 8 Kempner Institute for the Study of Natural and Artificial Intelligence, Harvard University, Allston, MA, USA 9 Broad Institute of MIT and Harvard, Cambridge, MA, USA 10 Harvard Data Science Initiative, Cambridge, MA, USA DOI: 10.1016/j.cell.2024.09.022 Also available on ScienceDirect User License: Creative Commons Attribution (CC BY 4.0) | Elsevier's open access license policy Download PDF Download PDF Outline Share Share on Email X Facebook LinkedIn Sina Weibo Mendeley bluesky Add to my reading list More Download PDF Download PDF Cite Share Share on Email X Facebook LinkedIn Sina Weibo Mendeley Bluesky Add to my reading list Set Alert Get Rights Reprints Download Full Issue Previous article Next article Figure 1 Empowering biomedical research with AI agents Show full caption Figure 2 Evolving use of data-driven models Show full caption Figure 3 Diverse configurations of AI agents in biomedicine—from an LLM-based AI agent to a multi-agent system with AI models, tools, and integrated physical devices Show full caption Table 1 Table 2 Table 3 Table 4 Figure 4 Key modules in AI agents: perception, interaction, reasoning, and memory modules Show full caption Figure 5 Illustration of components in biomedical AI agents Show full caption Figure 6 Challenges for AI agents in biomedical discovery Show full caption Shanghua Gao Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Ada Fang Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA Kempner Institute for the Study of Natural and Artificial Intelligence, Harvard University, Allston, MA, USA Yepeng Huang Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA Valentina Giunchiglia Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Department of Brain Sciences, Imperial College London, London, UK Ayush Noori Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Harvard College, Cambridge, MA, USA Jonathan Richard Schwarz Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Yasha Ektefaie Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Program in Biomedical Informatics, Harvard Medical School, Boston, MA, USA Jovana Kondic Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA Marinka Zitnik Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA Kempner Institute for the Study of Natural and Artificial Intelligence, Harvard University, Allston, MA, USA Broad Institute of MIT and Harvard, Cambridge, MA, USA Harvard Data Science Initiative, Cambridge, MA, USA Hide Caption Download See figure in Article Toggle Thumbstrip Download Hi-res image Download .PPT The content on this site is intended for healthcare professionals and researchers across all fields of science.We use cookies to help provide and enhance our service and tailor content. 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